We provide full diangostic service of Prion Infections (CJD, BSE, CWD):

Expected samples: For example, paraffin blocks should at least include one region of cerebral cortex, cerebellum and one subcortical gray matter region (e.g. basal
ganglia) in order to establish a diagnosis of CJD. Additional regions would
be important to establish or exclude other neurodegenerative disorders.

A detailed clinical history, including imaging and laboratory findings, if
possible, also would be helpful for us. Frozen material would be necessary
for a more formal exclusion of a prion disease or subclassification of CJD.
For a full diagnostic work-up, a western blot for proteinase K resistant
PrP can be also included. Certificate of diagnostic results will be issued
after detailed investigation.

Please contact: dr.wang@t-online.de

Figure Representation of Western blots of PrPTSE patterns of typical bovine spongiform encephalopathy (BSE) and the 2 major types of atypical BSE. M.W., molecular weight in kilodaltons; L type, atypical "light" pattern; H type, atypical "heavy" pattern.

On the Question of Sporadic or Atypical Bovine Spongiform Encephalopathy and Creutzfeldt-Jakob Disease

Paul Brown,* Lisa M. McShane,† Gianluigi Zanusso,‡ and Linda Detwiler§
*Bethesda, Maryland, USA; †National Institutes of Health, Bethesda, Maryland, USA; ‡University of Verona, Verona, Italy; and §Virginia-Maryland Regional College of Veterinary Medicine, College Park, Maryland, USA
Emerging Infectious Diseases Vol. 12, No. 12 • December 2006