Hepatitis E (HEV) was not recognized as a distinct human disease until 1980. Hepatitis E is caused by infection with the hepatitis E virus, a non-enveloped, positive-sense, single-stranded RNA virus. Although man is considered the natural host for HEV, antibodies to HEV or closely related viruses have been detected in primates and several other animal species.
In general, hepatitis E is a self-limiting viral infection followed by recovery. Prolonged viraemia or faecal shedding are unusual and chronic infection does not occur. Occasionally, a fulminant form of hepatitis develops, with overall patient population mortality rates ranging between 0.5% - 4.0%. Fulminate hepatitis occurs more frequently in pregnancy and regularly induces a mortality rate of 20% among pregnant women in the 3rd trimester.
Based on the epitopes of identified strains of HEV, ELISA kits for detection HEV specific IgG, IgA, and IgM antibodies after infection were developed. The kits were shown to be able to detect antibodies of other HEV strains appearing worldwide.
Cat.No.
Species
Antibody
SIZE
Link
HEV-HG-001
Human
IgG
96 wells
HEV-HA-001
Human
IgA
96 wells
HEV-HM-001
Human
IgM
96 wells
HEV-SG-001
Swine
IgG
96 wells
HEV-SA-001
Swine
IgA
96 wells
HEV-MG-001
Monkey
IgG
96 wells
HEV-CG-001
Chicken
IgG
96 wells
HEV-DG-001
Dog
IgG
96 wells
Other Reference HEV Kits
Cat.No.
Species
Ab
SIZE
Link
HEV-HG-002
Human
IgG
96 wells
HEV-HM-002
Human
IgM
96 wells
HEV-HT-002
Human
Total
96 wells
HEV-AG001
All
Antigen
96 wells
Antibodies
Cat.No.
Specificity
Ab
Epitope
Host
Qty
Link
HEV-PAB-0010
anti-HEV
PAB
ORF2
Rabbit
100µl
HEV-MAB-0011
anti-HEV
MAB
ORF2.1
mouse
100µg
HEV-MAB-0012
anti-HEV
MAB
ORF2.1
mouse
1mg
HEV-MAB-0021
anti-HEV
MAB
ORF2.2
mouse
100µg
HEV-MAB-0022
anti-HEV
MAB
ORF2.2
mouse
1mg
HEV-MAB-0031
anti-HEV
MAB
ORF2.3
mouse
100µg
HEV-MAB-0032
anti-HEV
MAB
ORF2.3
mouse
1mg
HEV-MAB-0041
anti-HEV
MAB
ORF2
mouse
100µl
HEV-MAB-0042
anti-HEV
MAB
ORF2
mouse
1ml
Application in immunohistohemistry (IHC), Enzymeimmunoassay (ELISA), Western Blot (WB)