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Cell Culture and Tissue Engineering
Please contact us if you
- want to produce recombinant glycoproteins according to cGMP standards or non-GMP
- look for efficient processes to produce biopharmaceuticals
- seek naturally glycosylated proteins
- intend to proliferate and harvest primary cells and stem cells for cell therapy
- need to achieve tissue-like growth of cells on implant scaffolds
| Code Nr. | Description | |
 | BR-1001 | Bioreactor, GMP Breeder, Control Unit |
| BR-1002 | Bioreactor | |
| BR-1003 | GMP Breeder | |
| BR-1004 | Control Unit | |
| BR-5001 | Cell carriers |
Bioreactor
A cultivation system comprises of Bioreactor, GMP Breeder and Control Unit. Conducted in the sterile environment of a GMP Breeder manifold types of cell and tissue culturing processes are feasible.
Features:
- fast and safe expansion of adherent cells
- three-dimensional high density cultivation in cell-specific extracellular matrix
- expansion and harvesting of viable primary cells for therapeutical applications
- expansion of stem cells with control of differentiation status
- colonization of scaffolds for implant generation long-term culturing of product secreting cell
- efficient production of recombinant proteins and vaccines
- production of excellently glycosylated proteins
The bioreactors are easy to assemble and handle. They are usually operated in perfusion mode and host large amounts of cells in very small volumes. The centrepiece is a magnetic coupled rotating axis mounted with the cell- or tissue carrier of choice exposing cells to medium and overlay alternately.
From highly porous cell carriers to implant scaffolds all kinds of supports can be installed in a bioreactor giving rise to a vast variety of culturing options. In all configurations best possible aeration and feeding is guaranteed. The gentle rotational motion stimulates cells and tissues to adhere and proliferate fast without being stressed by shear forces. Cell populations stay viable and express large amounts of extracellular matrix. Three-dimensional high density cultivation can be extended to many months without loosing viability or expression productivity. Harvest of adherent cells is easily achieved employing specific rotation programs in combination with detaching solutions.
Learn about our innovative bioreactors, cell carrier, tissue engineering platforms and scaffolds. Have a look at our range of services and use the advantages of our system for cultivation of adherent cell lines and primary cells. Cultures grow at high densities and form tissue-like structures. Cells behave similar to natural tissues in terms of division, morphology, differentiaton and metabolism, thus differing significantly from fermentor or bottle cultures. Please go to dr.wang@t-online.de
